WebFoxO3a (75D8) Rabbit mAb detects exogenous and endogenous levels of total FoxO3a protein. The antibody does not detect the exogenously expressed family members FoxO4 or FoxO1. Species Reactivity: Human, Mouse, Rat, Monkey Source / Purification Web(12829) FoxO3a (D19A7) Rabbit mAb Sign in or register to save this reagent to your favourites Supplier Cell Signaling Technology Host Rabbit Type Primary Clonality Recombinant (D19A7F3) Recombinant Yes Conjugate Unconjugated Target Forkhead box protein O3 (Human) UniProt O43524 - FOXO3_HUMAN Gene FOXO3 Modification …
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WebFOXO3a were positively correlated, and both were associated with longer sur-vival in lung cancer patients. Conclusion: Overall, the present study is the first to show that Adjudin syner-gizes with paclitaxel and inhibits cell growth and metastasis by regulating the SIRT3–FOXO3a axis in SCLC; thus, Adjudin has great potential to be an anti-
WebDec 1, 2016 · For example, FoxO3a activates FasL transcription, the ligand for the Fas-dependent cell death pathway or pro-apoptotic Bim gene and initiates apoptosis. FoxO3a also induces the expression of cell cycle progression inhibitors including p27 and CyclinD1, thus stalling the G1/S phase transition . Here, we investigated whether the survival … WebJul 17, 2003 · FOXO3a was cleaved in vitro by caspase-3-like proteases at the consensus sequence DELD304A, releasing the N-terminal DNA-binding domain of FOXO3a from its …
WebForkhead box O (FOXO) proteins are a family of transcription factors with four members in mammals, namely FOXO1, FOXO3a, FOXO4, and FOXO6. FOXO factors, originally … WebJun 28, 2024 · The following primary antibodies were used: Ubiquitin (#3933; Cell Signaling Technology (CST) Japan, Tokyo, Japan), p-Forkhead box O (FOXO) 1 Ser256 (#84192; CST), FOXO1 (#2880; CST), p-FOXO3a Ser253 (#9466; CST), FOXO3a (#2497; CST), LC3 (#2775; CST), p62/SQSTM (PM045, Medical & Biological Laboratory, Nagoya, Japan), p …
WebApr 22, 2024 · FOXO3a is a key target of AKT, and AKT phosphorylates FOXO3a at Thr32 residues, resulting in a decreased expression of FOXO3a. We then investigated whether …
WebThe FOXO3 and FOXM1 forkhead box transcription factors, functioning downstream of the essential PI3K-Akt, Ras-ERK and JNK/p38MAPK signalling cascades, are crucial for cell proliferation, differentiation, cell survival, senescence, DNA … crystal clinic hand centerWebDirections for Use: CST recommends transfection with 100 nM FoxO3a siRNA I 48 to 72 hours prior to cell lysis. For transfection procedure, follow protocol provided by the transfection reagent manufacturer. Please feel free to … crystal clinic emergency roomWebJan 1, 2012 · Doxorubicn treatment induces p38 MAPK activity and FOXO3a nuclear accumulation in MCF-7 breast carcinoma cell line. A, MCF-7 cells were treated with 1 μmol/liter of doxorubicin for 0, 1, 2, 4, 8, 16, and 24 h. At the indicated time, the cells were collected and analyzed by Western blotting using the antibodies indicated. dwarf fortress forbid eating seedsWebNov 1, 2024 · Results. Exercise can significantly attenuate AngⅡ-induced muscle atrophy, which is demonstrated by increased skeletal muscle weight, cross-sectional area of myofiber, and activation of AKT/mTOR signaling and by decreased atrogenes expressions and apoptosis. In AngⅡ-induced muscle atrophy mice models, PPARγ was elevated … dwarf fortress food rottingWebFOXO3a is a transcription factor of the FOXO family. The FOXO proteins participate in multiple signaling pathways, and their transcriptional activity is regulated by several post … crystal clinic employee drug testWebApr 11, 2024 · Nutrition during the developmental stages has long-term effects on adult physiology, disease and lifespan, and is termed nutritional programming. However, the underlying molecular mechanisms of nutritional programming are not yet well understood. In this study, we showed that developmental diets could regulate the lifespan of adult … dwarf fortress food storage itemWeb56484 Ensembl ENSG00000118689 ENSMUSG00000048756 UniProt O43524 Q9WVH4 RefSeq (mRNA) NM_001455 NM_201559 NM_019740 NM_001376967 RefSeq (protein) NP_001446 NP_963853 NP_062714 NP_001363896 Location (UCSC) Chr 6: 108.56 – 108.68 Mb Chr 10: 42.06 – 42.15 Mb PubMed search Wikidata View/Edit Human … dwarf fortress forbid cooking