Smad3 breast cancer
WebbHere, we report, for the first time, that mutation of the Smad3 linker phosphorylation sites markedly inhibited primary tumor growth, but significantly increased lung metastasis of breast cancer cell lines. In contrast, mutation of the Smad3 C-tail phosphorylation sites had the opposite effect. Webb8 dec. 2024 · Identification of Smad2 and Smad3 specific binding sites in a breast cancer cell line model: Organism: Homo sapiens: ... We identify Smad2 and Smad3 specific binding site in a breast cancer breast cell model MDA-MB-231 using LAP-tag GFP fusion proteins under the control of endogenous regulatory elements.
Smad3 breast cancer
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Webb14 mars 2013 · Beta-Elemene Blocks Epithelial-Mesenchymal Transition in Human Breast Cancer Cell Line MCF-7 through Smad3-Mediated Down-Regulation of Nuclear Transcription Factors Xian Zhang, Yinghua Li, Yang Zhang, Jincheng Song, Qimin Wang, Luping Zheng, Dan Liu x Published: March 14, 2013 … Webb14 dec. 2009 · Our results show that, depending on the type of R-Smad silenced the metastatic potential of the human breast cancer cells is differentially and significantly affected. Specific silencing of...
Webb4 apr. 2024 · these findings support the notion that Smad3 has important tumor suppressor function for breast cancer Treatment with metformin suppressed CCl4-induced expression of transforming growth factor beta 1 (TGF-beta1) and phosphorylation of Smad3. HSF1 activity is decreased in fibrotic hearts. Webb27 jan. 2024 · EZH2 -mediated SMAD3 K53/K333 methylation was upregulated and correlated with SMAD3 hyperactivation in breast cancer, promoted tumor metastasis, and was predictive of poor survival outcomes. We used 2 TAT peptides to abrogate SMAD3 methylation and therapeutically inhibit cancer metastasis.
Webb20 okt. 2024 · Aberrant SMAD3 activation has been implicated as a driving event in cancer metastasis, yet the underlying mechanisms are still elusive. Here, SMAD3 is identified as a nonhistone substrate of... Webbcontributes to trastuzumab resistance in HER2+ breast cancers. The goal of this study was to uncover a potential mechanism for trastuzumab resistance, focusing on altered, noncanonical phos-phorylation of SMAD3 in CCNE overexpressing HER2+ breast cancer cells, to help identify a new approach to restore the efficacy
WebbExpression of SMAD3 (HsT17436, JV15-2, MADH3) in cancer tissue. The cancer tissue page shows antibody staining of the protein in 20 different cancers. ... BREAST CANCER CARCINOID CERVICAL CANCER COLORECTAL CANCER ENDOMETRIAL CANCER GLIOMA HEAD AND NECK CANCER LIVER CANCER LUNG CANCER LYMPHOMA.
Webb4 mars 2010 · We stably knocked down Smad2 or Smad3 expression in MDA-MB-231 breast cancer cells. The TGF-beta-induced Smad3-mediated transcriptional response … cuore hair \u0026 esthetic salonWebbEffective inhibition of breast cancer stem cell properties by quercetin-loaded solid lipid nanoparticles via reduction of Smad2/Smad3 phosphorylation and β-catenin signaling … cuore bypassWebb1 dec. 2016 · Bcl-3 was required for the expression of downstream TGF β signaling genes that are involved in breast cancer lung metastasis. Bcl-3 knockdown enhanced the degradation of Smad3 but not Smad2... easy blueberry compote recipeWebb5 juli 2024 · Smad3 TGFβ triple negative breast cancer Introduction Triple negative breast cancer (TNBC) is an aggressive breast cancer subtype. Characterized by the absence of hormone receptor and Her2 receptor expression, it is unresponsive to anti-hormonal and Her2-targeted therapies. easy blueberry dessert recipeWebbEGFR is also essential for TGF-β-induced enhancement of these abilities of breast cancer cells. Canonical Smad3 signaling and ERK/Sp1 signaling pathways mediate TGF-β … easy blueberry crumb cake yellow cake mixWebbWe demonstrate attenuated SMAD3 transcriptional activity and SMAD protein expression in IBC, together with obliterated TGFβ1-induced IBC cell motility. The further reduction of … cu oregon state footballWebb11 okt. 2024 · Further, Smad3 is involved in a number of biological processes, including cell proliferation and differentiation, embryogenesis, angiogenesis, bone formation, tumorigenesis, and epithelial–mesenchymal transition (EMT) ( Wiercinska et al. 2011; Huang et al. 2024 ). cuore hair